Hungkuang University

Vice President/Dean, Division of Research & Development Affairs

張副 Dr. Tsong-Min Chang

Vice President

Dean, Office of Research and Development

No. 1018, Sec. 6, Taiwan Boulevard, Shalu Dist., Taichung City 433304, Taiwan
Tel: 886-4-2631-8652 ext. 2216
Fax: 886-4-2631-0744

Ph.D., National Cheng Kung University The Institute of Basic Medical Sciences
Bachelor, Kaohsiung Medical University School of Pharmacy

1. Hungkuang University: Vice President (2020.07.01~present)
2. Hungkuang University: Dept. Applied Cosmetology Distinguished Professor
3. Hungkuang University: Dean, Division of Research and Development Affairs
4. NATURAL BEAUTY: Consultant
5. Aicoming biotechnology Co.LTD: Consultant
6. ASIA Biotechnology & Cosmetology Association: Executive director
7. Procter & Gamble Greater China: Beauty skin care consultant
8. NIUER BEAUTY CO., LTD. : Chief R&D Technical Advisor
9. UMDNJ Visiting Scholar
10. Kuang Tien General Hospital Plastic & Reconstructive Cosmetic Surgery Center: Consultant

1. Development and design of natural products and herbal cosmetics
2. Development and application of whitening and anti-aging cosmetics
3. Development and design of medical cosmetics
4. Development and application of microbial metabolites in cosmetics

 Journal publications
1. Huey-Chun Huang , Wen-Ying Huang, Shao-Hua Chiu, Hui-Ju Ke, Shu-wen Chiu, Sze-Yun Wu, Feng-Sheng Kuo, Tsong-Min Chang*. Antimelanogenic and antioxidative properties of Bifidobacterium bifidum. Archives of Dermatological Research 2011, 303:527–531.

2. Huey-Chun Huang; Shao-Hua Chiu; Tsong-Min Chang*.Inhibitory Effect of [6]-Gingerol on Melanogenesis in B16F10 Melanoma Cells and Its Possible Mechanism of Action. Bioscience Biotechnology and Biochemistry 2011, 75: 1067-1072.
3. Tsong-Min Chang; Shi, GY; Wu, HL; Wu, CH; Su, YD; Wang, HL; Wen, HY; Huey-Chun Huang *. Effects of salvianolic Acid B on protein expression in human umbilical vein endothelial cells. Evidence-based complementary and alternative medicine; 2011: 213050.
4. Huey-Chun Huang, Tzu-Yun Chang, Long-Zen Chang, Hsiao-Fen Wang, Kuang-Hway Yih, Wan-Yu Hsieh, Tsong-Min Chang*. Inhibition of Melanogenesis Versus Antioxidant Properties of Essential Oil Extracted from Leaves of Vitex negundo Linn and Chemical Composition Analysis by GC-MS. Molecules 2012. 17, 3902-3916.
5. Huey-Chun Huang, Tsong-Min Chang* Antioxidative Characteristics of Anisomeles indica Extract and Inhibitory Effect of Ovatodiolide on Melanogenesis. International Journal of Molecular Sciences 2012, 13: 6220-6235.
6. Huey-Chun Huang, Wan-Yu Hsieh, Yu-Lin Niu, Tsong-Min Chang*. Inhibition of melanogenesis and antioxidant properties of Magnolia grandiflora L. flower extract. BMC Complementary Alternative Medicine 2012, 12: 72~81.
7. Huey-Chun Huang, Hsiao-Fen Wang, Kuang-Hway Yih, Long-Zen Chang, Tsong-Min Chang*. Dual Bioactivities of Essential Oil Extracted from the Leaves of Artemisia argyi as an Antimelanogenic versus Antioxidant Agent and Chemical Composition Analysis by GC/MS. International Journal of Molecular Sciences 2012,13 : 14679-14697.
8. Huey-Chun Huang, Hsiao-Fen Wang, Kuang-Hway Yih, Long-Zen Chang, Tsong-Min Chang*. The dual antimelanogenic and antioxidant activities of the essential oil extracted from the leaves of Acorus macrospadiceus. Evidence-based Complementary and Alternative Medicine 2012: 781280.
9. Huey-Chun Huang *, Tsong-Min Chang, Yu-Jia Chang, Hsin-Yun Wen. UVB Irradiation Regulates ERK1/2- and p53-Dependent Thrombomodulin Expression in Human Keratinocytes. PLoS ONE 2013. 8(7): e67632.
10. Huey-Chun Huang, Yin-Chun Chou, Chia-Yin Wu, Tsong-Min Chang*. [8]-Gingerol inhibits melanogenesis in murine melanoma cells through down-regulation of the MAPK and PKA signal pathways. Biochemical and Biophysical Research Communications 2013, 438:375-381.
11. Huey-Chun Huang, Shu-Jen Chang, Chia-Yin Wu, Hui-Ju Ke, and Tsong-Min Chang*. [6]-Shogaol Inhibits α-MSH-Induced Melanogenesis through the Acceleration of ERK and PI3K/Akt-Mediated MITF Degradation. BioMed Research International. Volume 2014, Article ID 842569, 9 pages
12. Huey-Chun Huang, Wen-Ying Huang, Tsang-Chi Tsai, Wan-Yu Hsieh, Wang-Ping Ko, Kuei-Jen Chang and Tsong-Min Chang*. Supercritical fluid extract of Lycium chinense Miller root inhibition of melanin production and its potential mechanisms of action. BMC Complementary and Alternative Medicine 2014, 14:208
13. Huey-Chun Huang, Wan-Yu Hsieh, Yu-Lin Niu and Tsong-Min Chang*. Inhibitory Effects of Adlay Extract on Melanin Production and Cellular Oxygen Stress in B16F10 Melanoma Cells. International Journal of Molecular Sciences 2014, 15, 16665-16679
14. Huey-Chun Huang、Ya-Chi Ho、Jia-Min Lim、Tzu-Yun Chang、Chen-Lung Ho、Tsong-Min Chang*. Investigation of the Anti-Melanogenic and Antioxidant Characteristics of Eucalyptus camaldulensis Flower Essential Oil and Determination of Its Chemical Composition. International Journal of Molecular Sciences, 2015, 16: 10470-10490.
15. Huey-Chun Huang, Chien-Mei Wei, Jen-Hung Siao, Tsang-Chi Tsai, Wang-Ping Ko, Kuei-Jen Chang, Choon-Hoon Hii, and Tsong-Min Chang*. Supercritical Fluid Extract of Spent Coffee Grounds Attenuates Melanogenesis through Downregulation of the PKA, PI3K/Akt, and MAPK Signaling Pathways. Evidence-Based Complementary and Alternative Medicine 2016, Article ID 5860296, 11 pages
16. Huey-Chun Huang, Chun-Chieh Liao, Chu-Chun Peng, Jia-Min Lim, Jen-Hung Siao, Chien-Mei Wei, Chien-Chih Chen, Chung-Shing Wu, Tsong-Min Chang*. Dihydromyricetin from Ampelopsis grossedentata inhibits melanogenesis through down-regulation of MAPK, PKA and PKC signaling pathways. CHEMICO-BIOLOGICAL INTERACTIONS.2016; 258: 166-174.
17. Tsong-Min Chang, Jen-Horng Tsen, Hsuan Yen, Ting-Ya Yang, and Huey-Chun Huang*. Extract from Periostracum cicadae Inhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine Volume 2017, Article ID 8325049, 12 pages (IF= 1.984, 10/27 in integrative and complementary medicine)
18. Tsong-Min Chang, Ting-Ya Yang, Yu-Lin Niu and Huey-Chun Huang. The Extract of D. dasycarpus Ameliorates Oxazolone-Induced Skin Damage in Mice by Anti-Inflammatory and Antioxidant Mechanisms. Antioxidants 2018, 7, 77; doi:10.3390/antiox7060077. 11 pages (IF=4.52, 6/61 in chemistry medicine)
19. Yu-Tsung Chen, Erh-Ti Lin, Chang-Cheng Chang, Bor-Shyh Lin, Hsiu-Mei Chiang, Yung-Hsueh Huang, Hui-Ying Lin, Ke-Yi Wang, and Tsong-Min Chang. Efficacy and Safety Evaluation of Picosecond Alexandrite Laser with a Diffractive Lens Array for Treatment of Melasma in Asian Patients by VISIA Imaging System. Photobiomodulation, Photomedicine, and Laser Surgery, 2019 Mary Ann Liebert, Inc. Pp. 1–8 DOI: 10.1089/photob.2019.4644 (IF = 1.913, 94/272 in medicine)
20. Y.-J. Wang, E.-T. Lin, Y.-T. Chen, P.-C. Chiu, B.-S. Lin, H.-M. Chiang, Y.-H. Huang, K.-Y. Wang, H.-Y. Lin, T.-M. Chang, C.-C. Chang*. Prospective randomized controlled trial comparing treatment efficacy and tolerance of picosecond alexandrite laser with a diffractive lens array and triple combination cream in female asian patients with melisma. 2019, Journal of the European Academy of Dermatology and Venereology DOI: 10.1111/jdv.15934 (IF=5.113, 6/66 in Dermatology) 
21. Huey Chun Huang, I Jung Lee, Chen Huang, Tsong Min Chang*. Lactic Acid Bacteria and Lactic acid for skin health and to Inhibit Melanogenesis. Current Pharmaceutical Biotechnology. 2020 (IF=1.516, 219/267 in pharmacology and pharmacy)
22. Huey-Chun Huang, Hsuan Yen, Ji-Ying Lu, Tsong-Min Chang*, Choon-Hoon Hii, Theophylli ne enhances melanogenesis in B16F10 murine melanoma cells through the activation of the MEK 1/2, and Wnt/β-catenin signaling pathways. Food and Chemical Toxicology, 2020.111165. (IF= 3.775, 18/93 in toxicology)
23. Huey-Chun Huang, JI-Ying Lu, Wen-Yang Chuang, Tsong-Min Chang*. Ginseng-Lactobacillus Ferment Exerts Synergistic Anti-Melanogenic Effects with Low Doses of Niacinamide In Vitro. 2020, Biomed J Sci & Tech Res | BJSTR. 19789-19797